Research group Group Ankarklev

Our team studies the biology underlying malaria transmission, with the ultimate goal of enabling novel strategies to hamper the spread of the disease.

Malaria has tremendous global impact, where nearly half the world’s population is at risk of acquiring the disease. The species, Plasmodium falciparum, which leads to the most severe form of disease, has been estimated to cause more than half a million deaths per year, mainly among young children. 

The highly complex lifecycle of Plasmodium falciparum involves transitioning between a human host and a mosquito vector. Our research group focuses on providing better understanding of the biology relating to parasite development and host-parasite interactions during the malaria transmission stages. We apply and develop genomic and computational tools that we use in combination with cell-biological and molecular methods to study genes and gene regulatory elements underlying malaria transmission with emphasis on; parasite cell differentiation and development, cell fate and host-pathogen interactions

This research group has no members.

There are no research project connections.

Host-pathogen interactions in the Plasmodium-infected mouse liver at spatial and single-cell - resolution. Hildebrandt F, Iturritza MU, Zwicker C, Vanneste B, Van Hul N, Semle E, Quin J, Pascini T, Saarenpää S, He M, Andersson ER, Scott CL, Vega-Rodriguez J, Lundeberg J, Ankarklev J. Nature Communications. 2024 Aug 19;15(1):7105. doi: 10.1038/s41467-024-51418-2

Spatial Transcriptomics to define transcriptional patterns of zonation and structural components in - the mouse liver. Hildebrandt F, Andersson A, Saarenpää S, Larsson L, Van Hul N, Kanatani S, Masek J, Ellis E, Barragan A, Mollbrink A, Andersson ER, Lundeberg J, Ankarklev J. Nature Communications. 2021 Dec 2;12(1):7046. doi: 10.1038/s41467-021-27354-w

Single-Cell Transcriptomics To Define Plasmodium falciparum Stage Transition in the Mosquito Midgut. - Mohammed M, Dziedziech A, Sekar V, Ernest M, Alves E Silva TL, Balan B, Emami SN, Biryukova I, Friedländer MR, Jex A, Jacobs-Lorena M, Henriksson J, Vega-Rodriguez J, Ankarklev J. Microbiol Spectr. 2023 Feb 27;11(2):e0367122. doi: 10.1128/spectrum.03671-22

Single-cell analysis of mosquito hemocytes identifies signatures of immune cell subtypes and cell - differentiation. Kwon H, Mohammed M, Franzén O, Ankarklev J, Smith RC. eLife. 2021 Jul 28;10:e66192. doi: 10.7554/eLife.66192

A Histone Methyltransferase Inhibitor Can Reverse Epigenetically Acquired Drug Resistance in the - Malaria Parasite Plasmodium falciparum. Chan A, Dziedziech A, Kirkman LA, Deitsch KW, Ankarklev J Antimicrob Agents Chemother. 2020 May 21;64(6):e02021-19. doi: 10.1128/AAC.02021-19

scDual-Seq of Toxoplasma gondii-infected mouse BMDCs reveals heterogeneity and differential - infection dynamics. Hildebrandt F, Mohammed M, Dziedziech A, Bhandage AK, Divne AM, Barrenäs F, Barragan A, Henriksson J, Ankarklev J Front Immunol. 2023 Jul 27;14:1224591. doi: 10.3389/fimmu.2023.1224591

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